Different integrins mediate cell spreading, haptotaxis and lateral migration of HaCaT keratinocytes on fibronectin
نویسندگان
چکیده
منابع مشابه
Fibronectin and integrins in cell adhesion and migration.
Introduction Fibronectin, other cell-adhesion molecules, and their integrin receptors appear to play important roles in cell migration during embryonic development, tumour-cell invasion and metastasis, and wound healing (reviewd in [ 11). Recent studies have defined critical peptide-recognition regions in fibronectin that are required for its interactions with cell-surface receptors. For exampl...
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An integrative cell migration model incorporating focal adhesion (FA) dynamics, cytoskeleton and nucleus remodeling, actin motor activity, and lamellipodia protrusion is developed for predicting cell spreading and migration behaviors. This work is motivated by two experimental works: (1) cell migration on 2-D substrates under various fibronectin concentrations and (2) cell spreading on 2-D micr...
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Keratinocytes and other epithelial cells express two receptors for the basement membrane (BM) extracellular matrix component laminin-5 (Ln-5), integrins alpha 3 beta 1 and alpha 6 beta 4. While alpha 3 beta 1 mediates adhesion, spreading, and migration (Kreidberg, J.A. 2000. Curr. Opin. Cell Biol. 12:548--553), alpha 6 beta 4 is involved in BM anchorage via hemidesmosomes (Borradori, L., and A....
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Changes in intracellular calcium concentration ([Ca²⁺]i) as well as in the phosphorylation state of proteins have been implicated in keratinocyte wound healing revealed in scratch assays. Scratching confluent HaCaT monolayers decreased the number of cells displaying repetitive Ca²⁺ oscillations as well as the frequency of their Ca²⁺-transients in cells close to the wounded area and initiated mi...
متن کاملIntegrins in cell migration.
Integrin-based adhesion has served as a model for studying the central role of adhesion in migration. In this article, we outline modes of migration, both integrin-dependent and -independent in vitro and in vivo. We next discuss the roles of adhesion contacts as signaling centers and linkages between the ECM and actin that allows adhesions to serve as traction sites. This includes signaling com...
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ژورنال
عنوان ژورنال: Cell Adhesion and Communication
سال: 1999
ISSN: 1029-2314
DOI: 10.3109/15419069909010806